I am an infectious disease physician-scientist with expertise in TB epidemiology, treatment and prevention, and HIV epidemiology. I have conducted several large multi-center epidemiologic and translational studies, as well as clinical trials, of TB and HIV. Together with Dr. Bruno Andrade at Fiocruz, I lead efforts for Regional Prospective Observational Research for TB (RePORT)-Brazil. I am the co-PI of RePORT-South Africa with Drs. Mark Hatherill and Thomas Scriba at the University of Cape Town. I am also a co-PI of RePORT-International, which coordinates and harmonizes RePORT research in Brazil, South Africa, India, China, Indonesia, the Philippines, South Korea, and Uganda. I am the director of the Epidemiology and Outcomes Unit of the Tennessee Center for AIDS Research; I established the Unit in 2003 and have led it since its inception. In addition, I participate in multi-center HIV cohort collaborations: 1) the North American ACCORD and 2) the Caribbean Central America South America network (CCASAnet), both in the International epidemiologic Databases to Evaluate AIDS (IeDEA) network; also 3) the CFAR Network of Integrated Clinical Systems (CNICS). The TB-Sentinel Research Network (TB-SRN), in which I also participate, collects data that are harmonized between RePORT-Brazil and IeDEA. I have successfully mentored early-stage investigators for academic positions and NIH funding, facilitated by 2 cycles of K24 funding. Since 1998, with continuous NIH funding, I have mentored 77 investigators, including 36 pre-doctoral and 41 post-doctoral trainees; 39 women and 37 under-represented minorities; 61 at U.S. and 16 at international institutions. Of these, there have been two F31, six T32, and 14 K awardees, and 13 with subsequent independent NIH R funding. I am well-suited to continue to serve as the Associate Director of the Developmental Core, and Director of the Epidemiology and Outcomes Unit of the Tennessee Center for AIDS Research.